ABSTRACT Purpose: To explore the neuroprotective effects of Lutongkeli (LTKL) in traumatic brain injury (TBI) and detect the related mechanism. Methods: TBI model was established with LTKL administration (2 and 4 g/kg/d, p.o.). Motor function of rats was examined by Rotarod test. Nissl staining was used to show neuron morphology. Furthermore, the disease-medicine common targets were obtained with the network pharmacology and analyzed with Kyoto Encyclopedia of Genes and Genomes. Lastly, the predicted targets were validated by real-time polymerase chain reaction. Results: After LTKL administration, neural behavior was significantly improved, and the number of spared neurons in brain was largely increased. Moreover, 68 bioactive compounds were identified, corresponding to 148 LTKL targets; 2,855 genes were closely associated with TBI, of which 87 overlapped with the LTKL targets and were considered to be therapeutically relevant. Functional enrichment analysis suggested LTKL exerted its pharmacological effects in TBI by modulating multiple pathways including apoptosis, inflammation, etc. Lastly, we found LTKL administration could increase the mRNA level of Bcl-2 and decrease the expression of Bax and caspase-3. Conclusions: This study reported the neuroprotective effect of LTKL against TBI is accompanied with anti-apoptosis mechanism, which provides a scientific explanation for the clinical application of LTKL in the treatment of TBI.

Resumo Objetivo: O presente artigo destaca a interação entre a inovação e a estrutura financeira segundo o conceito de duopólio com um debatedor de monopólio. Metodologia: Por meio de abordagens de teorias de jogos, caracterizamos os efeitos dos níveis de dívida em investimentos inovadores com efeito da responsabilidade limitada. Resultados: O presente artigo argumenta que níveis mais altos de dívida aumentam tanto os investimentos quanto os resultados. Tanto a taxa de dívida mais alta quanto os níveis de dívida mais altos atuam como um compromisso com a redução dos lucros líquidos das empresas concorrentes. O lucro líquido por dívida unitária é reduzido com maior nível de dívida e maior taxa de dívida. Contribuições: O presente artigo expande o trabalho de Brander e Lewis (1986) para uma situação inovadora, sem a restrição de uma solução de ponto interior.

Abstract Purpose: This paper highlights the interaction between innovation and financial structure under duopoly with a monopoly debater. Design/methodology/approach: By game-theory approaches, we characterize effects of debt levels on innovative investment with limited liability effect. Findings: This paper argues that higher debt levels increase both innovative investment and output. Both higher debt rate and higher debt levels act as commitment to reduce opponent firms’ net profits. Net profit for unit debt is reduced with higher debt level and higher debt rate. Originality/value: This study extends Brander and Lewis’s (1986) to innovative situation and no interior point solution is restricted.

RESUMEN El sondeo remoto del agua ecológica (del inglés Eco-water, agua conservada en la superficie terrestre) es indispensable en la investigación sistemática y cuantitativa de las fuentes de agua. Los niveles de suministros de agua ecológica indican la capacidad de conservación de la capa de agua ecológica y la influencia de esta en la transformación de precipitación y la regulación de escorrentía. La inversión cuantitativa por sondeo remoto estableció el Módulo de Conservación de Agua Ecológica (MEC, del inglés Modulus of Eco-Water Conservation) para el área de estudio en la cuenca alta del río Minjiang entre 1994 y 2001, y combinada con la información climática de entre 1990 y 2005, se analizó la influencia de conservacion de agua en la capa ecoacuática. Los resultados mostraron una gran eficacia en el control de inundaciones y en el suministro de agua durante la sequía a lo largo del ciclo hidrológico. Por esta razón, la protección y restauración de la capa de agua ecológica para la prevención de inundaciones y sequía es necesaria.

ABSTRACT Remote sensing quantitative retrieval of ecological water (eco-water) has been foundational in systemic and quantitative research for water resources. Eco-water resource levels indicate conservation ability for the eco-water layer and influence of this on precipitation transformation and runoff regulation. The remote sensing quantitative inversion retrieved the MEC (Modulus of eco-water Conservation) of the Upper Minjiang River Basin study area in 1994 and 2001, and combined with climate data between 1990 and 2005, the influence of conservation water on the eco-water layer on runoff was then analyzed. Results revealed significant efficacy for flood control and water supply during the drought from the hydrologic cycle of eco-water. Thus protection and restoration of the eco-water layer for flood and drought prevention are crucial.

Abstract A feature based relation classification approach is presented in this paper. We aimed to exact relation candidates from Wikipedia texts. A probabilistic and a semantic relatedness features are employed with other linguistic information for the purpose. The experiments show that, relation classification using the proposed relatedness features with surface information like word and part-of-speech tags is competitive with or even outperforms the one of using deep syntactic information. Meanwhile, an approach is proposed to distinguish reliable relation candidates from others, so that these reliable results can be accepted for knowledge building without human verification. The experiments show that, with the relation classification approach presented in this paper, more than 40% of the classification results are reliable, which means, at least 40% of the human and time costs can be saved in practice.

A series of unsaturated esters were prepared via condensation of sodium carboxylates and alkenyl halide under the condition of macroporous polystyrene grafted quarternary ammonium salt as recyclable phase transfer catalyst, NaI as co-catalyst, Cu powder as inhibitor and H2O as solvent. Under optimal conditions, products yields are 78.2~ 96.0%. The catalyst can be convenient recycled and reutilized for about five times without losing its activity obviously.

There are very few microbiological data on wound infections following snakebites. The objective of this study was to investigate the treatment of secondary infection following snakebites in central Taiwan. Microbiological data and antibiotic sensitivity of wound cultures were retrospectively analyzed from December 2005 to October 2007 in a medical center in central Taiwan. A total of 121 snakebite patients participated in the study. Forty-nine (40.5%) subjects were bitten by cobra (Naja atra); 34 of them had secondary infection, and 24 of them (70.6%) needed surgical intervention. Cobra bites caused more severe bacterial infection than other snakebites. Morganella morganii was the most common pathogen, followed by Aeromonas hydrophila and Enterococcus. Gram-negative bacteria were susceptible to amikacin, trimethoprim/sulfamethoxazole, cefotaxime, cefepime, ciprofloxacin, and piperacillin/tazobactam. Enterococcus were susceptible to ampicillin, gentamicin, penicillin and vancomycin. It is reasonable to choose piperacillin/tazobactam, quinolone, second- or third-generation cephalosporin for empirical therapy following snakebite. Surgical intervention should be considered for invasive soft tissue infections.

OBJECTIVE: Infections of snake bite wounds by Shewanella are rarely discussed in the medical literature. This study aims to characterize the presentation and management of Shewanella infections in snake bite wounds. METHOD: We retrospectively investigated the microbiology, clinical features, and outcomes of patients with Shewanella infected snake bite wounds admitted to a tertiary medical center from January 1998 to December 2009. RESULTS: Ten patients with Shewanella-infected snake bite wounds were identified. All of the snake bites were caused by cobras. The majority of patients had moderate to severe local envenomation and polymicrobial infections. Shewanella isolates are susceptible to ampicillin-sulbactam, piperacillin-tazobactam, third-and fourthgeneration cephalosporins, carbapenems, aminoglycosides, and quinolones but are resistant to penicillin and cefazolin. All of the patients examined had favorable outcomes. CONCLUSION: It is recommended that Shewanella infection be considered in snake bite patients, especially when patients present with moderate to severe local envenomation.